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KMID : 0366220070420030258
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Korean Journal of Hematology
2007 Volume.42 No. 3 p.258 ~ p.263
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Therapeutic Efficacy of a Single Dose of Anti-D Immunoglobulin 50μg/kg in Childhood Acute Immune Thrombocytopenic Purpura
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Nam Ki-Lyong
Cho Sang-Hee
Yang Sung-Wan
Son Dong-Woo
Jeon In-Cheol
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Abstract
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Background: To investigate the efficacy and adverse effects of a single dose of anti-D immunoglobulin (50μg/kg) in Korean children with acute immune thrombocytopenic purpura (ITP).
Methods:We serially evaluated the platelet count in 21 acute ITP patients that were treated with anti-D immunoglobulin (50μg/kg) to determine how many patients achieved platelet counts over the levels of 20×103/mm3, 50×103/mm3 and 100×103/mm3 after the infusion of anti-D immunoglobulin. In addition, constitutional symptoms were monitored and changes in the hemoglobin levels were serially evaluated.
Results:By three days after treatment, 90.5% of the patients had achieved a platelet count over 20× 103/mm3. At seven days after treatment, 66.7% of patients achieved a platelet count of 50×103/mm3. In addition, at seven days after treatment 61.9% of patients achieved a platelet count of 100×103/mm3. Constitutional adverse symptoms were observed 61.9% of patients, and the symptoms diminished spontaneously without any severe sequelaes. The decline of hemoglobin concentration after treatment recovered to the initial level after two weeks.
Conclusion:A single dose of anti-D immunoglobulin (50μg/kg)was effective in Korean children with acute ITP to raise the platelet count rapidly. The adverse effects of anti-D immunoglobulin, including hemolytic anemia, were not severe to prevent the use of the anti-D
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KEYWORD
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Immune thrombocytopenic purpura (ITP), Anti-D, Hemolytic anemia
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